GLP-1 drugs led to weight loss and reversed depression-like behavior in mice

# Summary Recent research shows that GLP-1 drugs like Ozempic not only promote weight loss but also reverse depression-like behavior in mice through gut microbes rather than the drug's primary mechanism. The antidepressant effect depends on a specific bacterium, *Lactobacillus delbrueckii*, which GLP-1 drugs help produce endocannabinoids—natural compounds that reduce stress effects on mood-related brain regions. The finding was confirmed when depressed mice receiving fecal transplants from GLP-1-treated mice showed similar mood improvements, suggesting gut microbes are key to the psychiatric benefits.