Objective metrics that change the most as we age

The article identifies the biomarkers that change most significantly with age, with kidney function (eGFR) showing the steepest decline at roughly 6-7 points per decade, followed by hemoglobin A1c rising about 0.1 percent per decade as glucose intolerance increases. However, the article emphasizes that these declines are not inevitable—maintaining healthy blood pressure, fasting glucose levels, regular exercise, and stable weight can substantially slow or even prevent these age-related changes in many people.